Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015) A unique view on male infertility around the globe. Reprod Biol Endocrinol 13:37
Article
PubMed
PubMed Central
Google Scholar
Hammoud AO, Meikle AW, Reis LO, Gibson M, Peterson CM, Carrell DT (2012) Obesity and male infertility: a practical approach, seminars in reproductive medicine. Semin Reprod Med 30:486–495
Leisegang K, Dutta S (2021) Do lifestyle practices impede male fertility? Andrologia. 53:e13595
Article
PubMed
Google Scholar
Katib A (2015) Mechanisms linking obesity to male infertility. Centr Eur J Urol 68:79
Google Scholar
Sengupta P (2015) Reviewing reports of semen volume and male aging of last 33 years: from 1980 through 2013. Asian Pac J Reprod 4:242–246
Article
Google Scholar
Sengupta P, Dutta S, Krajewska-Kulak E (2017) The disappearing sperms: analysis of reports published between 1980 and 2015. Am J Mens Health 11:1279–1304
Article
PubMed
Google Scholar
Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E (2018) Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol 37:247–255
Article
CAS
PubMed
Google Scholar
Sengupta P, Nwagha U, Dutta S, Krajewska-Kulak E, Izuka E (2017) Evidence for decreasing sperm count in African population from 1965 to 2015. Afr Health Sci 17:418–427
Article
PubMed
PubMed Central
Google Scholar
Sengupta P, Dutta S, Tusimin MB, İrez T, Krajewska-Kulak E (2018) Sperm counts in asian men: reviewing the trend of past 50 years. Asian Pac J Reprod 7:87–92
Article
Google Scholar
El Salam MAA (2018) Obesity, an enemy of male fertility: a mini review. Oman Med J 33:3
Article
PubMed
PubMed Central
Google Scholar
Hammoud AO, Gibson M, Peterson CM, Meikle AW, Carrell DT (2008) Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril 90:897–904
Article
PubMed
Google Scholar
Craig JR, Jenkins TG, Carrell DT, Hotaling JM (2017) Obesity, male infertility, and the sperm epigenome. Fertil Steril 107:848–859
Article
PubMed
Google Scholar
Wahid B, Bashir H, Bilal M, Wahid K, Sumrin A (2017) Developing a deeper insight into reproductive biomarkers. Clin Exp Reprod Med 44:159–170
Article
PubMed
PubMed Central
Google Scholar
Palmer NO, Bakos HW, Fullston T, Lane M (2012) Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis. 2:253–263
Article
PubMed
PubMed Central
Google Scholar
MacDonald A, Herbison G, Showell M, Farquhar C (2009) The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update 16:293–311
Article
PubMed
Google Scholar
Sallmén M, Sandler DP, Hoppin JA, Blair A, Baird DD (2006) Reduced fertility among overweight and obese men. Epidemiology.:520–523
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R (2010) Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 93:2222–2231
Article
CAS
PubMed
Google Scholar
Ahirwar R, Mondal PR (2019) Prevalence of obesity in India: a systematic review. Diabetes Metab Syndr Clin Res Rev 13:318–321
Article
Google Scholar
Vogels A, Moerman P, Frijns J-P, Bogaert GA (2008) Testicular histology in boys with Prader-Willi syndrome: fertile or infertile? J Urol 180:1800–1804
Article
PubMed
Google Scholar
Álvarez-Satta M, Castro-Sánchez S, Valverde D (2015) Alström syndrome: current perspectives. Appl Clin Genet 8:171
PubMed
PubMed Central
Google Scholar
Koscinski I, Mark M, Messaddeq N, Braun JJ, Celebi C, Muller J et al (2020) Reproduction function in male patients with Bardet Biedl syndrome. J Clin Endocrinol Metab 105:e4417–e4429
Article
PubMed Central
Google Scholar
Sengupta P (2014) Recent trends in male reproductive health problems. Asian J Pharm Clin Res 7:1–5
Google Scholar
Sengupta P (2014) Current trends of male reproductive health disorders and the changing semen quality. Int J Prev Med 5:1
PubMed
PubMed Central
Google Scholar
Butler G, M. (2011) Prader-Willi syndrome: obesity due to genomic imprinting. Curr Genomics 12:204–215
Article
CAS
PubMed
PubMed Central
Google Scholar
Kasum M, Anić-Jurica S, Čehić E, Klepac-Pulanić T, Juras J, Žužul K (2016) Influence of male obesity on fertility. Acta Clin Croat 55:301–308
Article
PubMed
Google Scholar
Potabattula R, Dittrich M, Schorsch M, Hahn T, Haaf T, El Hajj N (2019) Male obesity effects on sperm and next-generation cord blood DNA methylation. PLoS One 14:e0218615
Article
CAS
PubMed
PubMed Central
Google Scholar
Fullston T, Teague EMCO, Palmer NO, DeBlasio MJ, Mitchell M, Corbett M, Print CG, Owens JA, Lane M (2013) Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microrna content. FASEB J 27:4226–4243
Article
CAS
PubMed
Google Scholar
Palmer NO, Fullston T, Mitchell M, Setchell BP, Lane M (2011) Sirt6 in mouse spermatogenesis is modulated by diet-induced obesity. Reprod Fertil Dev 23:929–939
Article
CAS
PubMed
Google Scholar
Consales C, Toft G, Leter G, Bonde JPE, Uccelli R, Pacchierotti F et al (2016) Exposure to persistent organic pollutants and sperm DNA methylation changes in Arctic and European populations. Environ Mol Mutagen 57:200–209
Article
CAS
PubMed
Google Scholar
Wangsri S, Subbalekha K, Kitkumthorn N, Mutirangura A (2012) Patterns and possible roles of LINE-1 methylation changes in smoke-exposed epithelia. PLoS One 7:e45292
Article
CAS
PubMed
PubMed Central
Google Scholar
Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L et al (2016) Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab 23:369–378
Article
CAS
PubMed
Google Scholar
Bastardot F, Marques-Vidal P, Vollenweider P (2019) Association of body temperature with obesity. The colaus study. Int J Obes (Lond) 43:1026
Article
Google Scholar
Darbandi M, Darbandi S, Agarwal A, Sengupta P, Durairajanayagam D, Henkel R, Sadeghi MR (2018) Reactive oxygen species and male reproductive hormones. Reprod Biol Endocrinol 16:1–14
Article
Google Scholar
Calderón B, Gómez-Martín JM, Vega-Piñero B, Martín-Hidalgo A, Galindo J, Luque-Ramírez M, Escobar-Morreale HF, Botella-Carretero JI (2016) Prevalence of male secondary hypogonadism in moderate to severe obesity and its relationship with insulin resistance and excess body weight. Andrology. 4:62–67
Article
PubMed
Google Scholar
Dandona P, Dhindsa S (2011) Update: hypogonadotropic hypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab 96:2643–2651
Article
CAS
PubMed
PubMed Central
Google Scholar
Esposito K, Giugliano D (2005) Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 17:391–398
Article
CAS
PubMed
Google Scholar
Mushannen T, Cortez P, Stanford FC, Singhal V (2019) Obesity and hypogonadism—a narrative review highlighting the need for high-quality data in adolescents. Children. 6:63
Article
PubMed Central
Google Scholar
Dhindsa S, Furlanetto R, Vora M, Ghanim H, Chaudhuri A, Dandona P (2011) Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care 34:1854–1859
Article
CAS
PubMed
PubMed Central
Google Scholar
Stanworth R, Jones T (2009) Testosterone in obesity, metabolic syndrome and type 2 diabetes. Front Horm Res. 37:74–90
Svartberg J (2007) Epidemiology: testosterone and the metabolic syndrome. Int J Impot Res 19:124–128
Article
CAS
PubMed
Google Scholar
Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S et al (2007) Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf) 66:440–446
Article
CAS
Google Scholar
Cohen P (2001) Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypotheses 56:702–708
Article
CAS
PubMed
Google Scholar
Hanchang W, Semprasert N, Limjindaporn T, Yenchitsomanus P-t, Kooptiwut S (2013) Testosterone protects against glucotoxicity-induced apoptosis of pancreatic β-cells (INS-1) and male mouse pancreatic islets. Endocrinology. 154:4058–4067
Article
CAS
PubMed
Google Scholar
Gianatti E, Grossmann M (2020) Testosterone deficiency in men with type 2 diabetes: pathophysiology and treatment. Diabet Med 37:174–186
Article
CAS
PubMed
Google Scholar
Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S (2003) Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 144:5081–5088
Article
CAS
PubMed
Google Scholar
Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with β-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 147:141–154
Article
CAS
PubMed
Google Scholar
Svartberg J, von Muhlen D, Schirmer H, Barrett-Connor E, Sundfjord J, Jorde R (2004) Association of endogenous testosterone with blood pressure and left ventricular mass in men. The tromso study. Eur J Endocrinol 150:65–72
Article
CAS
PubMed
Google Scholar
Traish AM, Feeley RJ, Guay A (2009) Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. FEBS J 276:5755–5767
Article
CAS
PubMed
Google Scholar
Ding EL, Song Y, Malik VS, Liu S (2006) Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 295:1288–1299
Article
CAS
PubMed
Google Scholar
Caliber M, Saad F (2021) Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone. Curr Opin Pharmacol 58:83–89
Article
CAS
PubMed
Google Scholar
Pasquali R, Macor C, Vicennati V, De Iasio FR, Mesini P, Boschi S, Casimirri F, Vettor R (1997) Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men. Metab Clin Exp 46:526–529
Article
CAS
PubMed
Google Scholar
Pasquali R, Casimirri F, De Iasio R, Mesini P, Boschi S, Chierici R, Flamia R, Biscotti M, Vicennati V (1995) Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab 80:654–658
CAS
PubMed
Google Scholar
Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ (2004) Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 27:861–868
Article
CAS
PubMed
Google Scholar
Benitez A, Diaz JP (1985) Effect of streptozotocin-diabetes and insulin treatment on regulation of Leydig cell function in the rat. Horm Metab Res 17:5–7
Article
CAS
PubMed
Google Scholar
Cole AP, Hanske J, Jiang W, Kwon NK, Lipsitz SR, Kathrins M et al (2018) Impact of testosterone replacement therapy on thromboembolism, heart disease and obstructive sleep apnoea in men. BJU Int 121:811–818
Article
CAS
PubMed
Google Scholar
Song C, Ma H-P, Eaton DC (2020) Epithelial sodium channels (ENaC). In: Studies of epithelial transporters and ion channels. Springer, pp 697–803
Cai Y, Li J, Jia C, He Y, Deng C (2020) Therapeutic applications of adipose cell-free derivatives: a review. Stem Cell Res Ther 11:1–16
Article
Google Scholar
Seccia TM, Caroccia B, Gomez-Sanchez EP, Gomez-Sanchez CE, Rossi GP (2018) The biology of normal zona glomerulosa and aldosterone-producing adenoma: pathological implications. Endocr Rev 39:1029–1056
PubMed
PubMed Central
Google Scholar
Kooptiwut S, Hanchang W, Semprasert N, Junking M, Limjindaporn T, Yenchitsomanus P-t (2015) Testosterone reduces AGTR1 expression to prevent B-cell and islet apoptosis from glucotoxicity. J Endocrinol 224:215–224
Article
CAS
PubMed
Google Scholar
Sengupta P (2017) An update on coagulating gland renin-angiotensin-prostaglandin system: a new hypothesis on its renin function. Asian J Pharm Clin Res 10:47–52
Article
CAS
Google Scholar
Hirata A, Maeda N, Hiuge A, Hibuse T, Fujita K, Okada T, Kihara S, Funahashi T, Shimomura I (2009) Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res 84:164–172
Article
CAS
PubMed
Google Scholar
MacADAMS MR, White RH, CHIPPS BE. (1986) Reduction of serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 104:648–651
Article
CAS
PubMed
Google Scholar
Welsh TH Jr, Bambino TH, Hsueh AJ (1982) Mechanism of glucocorticoid-induced suppression of testicular androgen biosynthesis in vitro. Biol Reprod 27:1138–1146
Article
CAS
PubMed
Google Scholar
Bhattacharya K, Sengupta P, Dutta S, Karkada I (2020) Obesity, systemic inflammation and male infertility. Chem Biol Lett 7:92–98
CAS
Google Scholar
Lee MJ, Pramyothin P, Karastergiou K, Fried SK (2014) Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity. Biochim Biophys Acta 1842:473–481
Article
CAS
PubMed
Google Scholar
Rao R, Somvanshi P, Klerman EB, Marmar C, Doyle FJ (2021) Modeling the influence of chronic sleep restriction on cortisol circadian rhythms, with implications for metabolic disorders. Metabolites. 11:483
Article
CAS
PubMed
PubMed Central
Google Scholar
Vicennati V, Ceroni L, Gagliardi L, Pagotto U, Gambineri A, Genghini S, Pasquali R (2004) Response of the hypothalamic-pituitary-adrenal axis to small dose arginine-vasopressin and daily urinary free cortisol before and after alprazolam pre-treatment differs in obesity. J Endocrinol Invest 27:541–547
Article
CAS
PubMed
Google Scholar
Bertagna X, Coste J, Raux-Demay M, Letrait M, Strauch G (1994) The combined corticotropin-releasing hormone/lysine vasopressin test discloses a corticotroph phenotype. J Clin Endocrinol Metab 79:390–394
CAS
PubMed
Google Scholar
Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate A, Barbara L (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341–346
CAS
PubMed
Google Scholar
Li XF, Kinsey-Jones JS, Cheng Y, Knox AM, Lin Y, Petrou NA et al (2009) Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One 4:e8334
Mihalca R, Fica S (2014) The impact of obesity on the male reproductive axis. J Med Life 7:296
CAS
PubMed
PubMed Central
Google Scholar
Dudek M, Kołodziejski PA, Pruszyńska-Oszmałek E, Sassek M, Ziarniak K, Nowak KW, Sliwowska JH (2016) Effects of high-fat diet-induced obesity and diabetes on kiss1 and gpr54 expression in the hypothalamic-pituitary-gonadal (hpg) axis and peripheral organs (fat, pancreas and liver) in male rats. Neuropeptides. 56:41–49
Article
CAS
PubMed
Google Scholar
Clarkson J, Han SY, Piet R, McLennan T, Kane GM, Ng J et al (2017) Definition of the hypothalamic GnRH pulse generator in mice. Proc Natl Acad Sci 114:E10216–e10223
Article
CAS
PubMed
PubMed Central
Google Scholar
Han SY, McLennan T, Czieselsky K, Herbison AE (2015) Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion. Proc Natl Acad Sci 112:13109–13114
Article
CAS
PubMed
PubMed Central
Google Scholar
Wolfe A, Hussain MA (2018) The emerging role(s) for kisspeptin in metabolism in mammals. Front Endocrinol 9:184
Article
Google Scholar
Holmes D (2014) Metabolism: kisspeptin signalling linked to obesity. Nat Rev Endocrinol 10:511
Article
PubMed
Google Scholar
Pavlopoulou A, Lambrou GI, Koutelekos J, Cokkinos D, Albanopoulos K, Chrousos GP (2021) Kisspeptin and the genetic obesity interactome. Adv Exp Med Biol 1339:111–117
Article
PubMed
Google Scholar
de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the kiss1-derived peptide receptor gpr54. Proc Natl Acad Sci 100:10972–10976
Article
PubMed
PubMed Central
Google Scholar
Pasquali R, Patton L, Gambineri A (2007) Obesity and infertility. Curr Opinion Endocrinol Diab Obes 14:482–487
Article
Google Scholar
Wahab F, Shahab M, Behr R (2015) The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction. J Endocrinol 225:R49–R66
Article
CAS
PubMed
Google Scholar
Al Hayek AA, Khader YS, Jafal S, Khawaja N, Robert AA, Ajlouni K (2013) Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional study. J Fam Community Med 20:179–186
Article
Google Scholar
Winters SJ, Wang C, Abdelrahaman E, Hadeed V, Dyky MA, Brufsky A (2006) Inhibin-b levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells? J Androl 27:560–564
Article
CAS
PubMed
Google Scholar
Kumanov P, Nandipati K, Tomova A, Agarwal A (2006) Inhibin b is a better marker of spermatogenesis than other hormones in the evaluation of male factor infertility. Fertil Steril 86:332–338
Article
CAS
PubMed
Google Scholar
Yen J-Y, Lin H-C, Lin P-C, Liu T-L, Long C-Y, Ko C-H (2020) Leptin and ghrelin concentrations and eating behaviors during the early and late luteal phase in women with premenstrual dysphoric disorder. Psychoneuroendocrinology. 118:104713
Article
CAS
PubMed
Google Scholar
Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A (2001) Leptin in reproduction. Trends Endocrinol Metab 12:65–72
Article
CAS
PubMed
Google Scholar
Zorn B, Osredkar J, Meden-Vrtovec H, Majdic G (2007) Leptin levels in infertile male patients are correlated with inhibin b, testosterone and SHBG but not with sperm characteristics. Int J Androl 30:439–444
Article
CAS
PubMed
Google Scholar
Yamagishi S-i, Edelstein D, Du X-l, Kaneda Y, Guzmán M, Brownlee M (2001) Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase a. J Biol Chem 276:25096–25100
Article
CAS
PubMed
Google Scholar
Wauters M, Considine RV, Van Gaal LF (2000) Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 143:293–312
Article
CAS
PubMed
Google Scholar
Martin LJ (2014) Implications of adiponectin in linking metabolism to testicular function. Endocrine. 46:16–28
Article
CAS
PubMed
Google Scholar
Dupont C, Faure C, Sermondade N, Boubaya M, Eustache F, Clément P et al (2013) Obesity leads to higher risk of sperm DNA damage in infertile patients. Asian J Androl 15:622
Article
CAS
PubMed
PubMed Central
Google Scholar
Dupont J, Maillard V, Coyral-Castel S, Ramé C, Froment P (2010) Ghrelin in female and male reproduction. Int J Pept 2010:158102
Pagotto U, Gambineri A, Pelusi C, Genghini S, Cacciari M, Otto B, Castañeda T, Tschöp M, Pasquali R (2003) Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J Clin Endocrinol Metab 88:4139–4143
Article
CAS
PubMed
Google Scholar
Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M (2007) Ghrelin expression in human testis and serum testosterone level. J Androl 28:320–324
Article
CAS
PubMed
Google Scholar
Suzuki H, Matsuzaki J, Hibi T (2010) Ghrelin and oxidative stress in gastrointestinal tract. J Clin Biochem Nutr. 48:122–125
Ahima RS (2006) Metabolic actions of adipocyte hormones: focus on adiponectin. Obesity. 14:9S–15S
Article
CAS
PubMed
Google Scholar
Page ST, Herbst KL, Amory JK, Coviello AD, Anawalt BD, Matsumoto AM, Bremner WJ (2005) Testosterone administration suppresses adiponectin levels in men. J Androl 26:85–92
CAS
PubMed
Google Scholar
Dutta S, Sengupta P, Chakravarthi S, Irez T, Baktir G (2021) Adiponectin:‘a metabolic ballcock’modulating immune responses and male reproduction. Chem Biol Lett 8:171–182
CAS
Google Scholar
Moretti E, Collodel G, Iacoponi F, Geminiani M, Pascarelli NA, Campagna S, Franci B, Figura N (2011) Detection of obestatin in seminal plasma and its relationship with ghrelin and semen parameters. Fertil Steril 95:2303–2309
Article
CAS
PubMed
Google Scholar
Jahan S, Sidrat T, Ahmed S, Wazir H, Ullah K (2011) Effect of obestatin on morphometry of testes and testosterone secretion in male rats. Afr J Biotechnol 10:7717–7722
CAS
Google Scholar
Irez T, Bicer S, Sahin S, Dutta S, Sengupta P (2020) Cytokines and adipokines in the regulation of spermatogenesis and semen quality. Chem Biol Lett 7:131–139
CAS
Google Scholar
Dutta S, Sengupta P, Jegasothy R, Akhigbe R (2021) Resistin and visfatin:‘connecting threads’ of immunity, energy modulations and male reproduction. Chem Biol Lett 8:192–201
CAS
Google Scholar
Kasturi SS, Tannir J, Brannigan RE (2008) The metabolic syndrome and male infertility. J Androl 29:251–259
Article
CAS
PubMed
Google Scholar
Tsatsanis C, Dermitzaki E, Avgoustinaki P, Malliaraki N, Mytaras V, Margioris AN (2015) The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis. Hormones. 14:549–562
Article
PubMed
Google Scholar
Zheng L-Y, Xu X, Wan R-H, Xia S, Lu J, Huang Q (2019) Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes. Diabetol Metab Syndr 11:1–7
Article
Google Scholar
Moretti E, Collodel G, Mazzi L, Campagna M, Iacoponi F, Figura N (2014) Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele. Fertil Steril 102:354–360
Article
CAS
PubMed
Google Scholar
Theam OC, Dutta S, Sengupta P (2020) Role of leucocytes in reproductive tract infections and male infertility. Chem Biol Lett 7:124–130
CAS
Google Scholar
Sengupta P, Dutta S, Tusimin M, Karkada IR (2019) Orexins and male reproduction. Asian Pac J Reprod 8:233
Article
CAS
Google Scholar
Duffy CM, Nixon JP, Butterick TA (2016) Orexin a attenuates palmitic acid-induced hypothalamic cell death. Mol Cell Neurosci 75:93–100
Article
CAS
PubMed
PubMed Central
Google Scholar
Zheng D, Zhao Y, Shen Y, Chang X, Ju S, Guo L (2014) Orexin a-mediated stimulation of 3β-hsd expression and testosterone production through mapk signaling pathways in primary rat Leydig cells. J Endocrinol Invest 37:285–292
Article
CAS
PubMed
Google Scholar
Sengupta P, Hassan MF, Dutta S, Jegasothy R, Chhikara BS (2021) Orexins: the ‘multitasking’neuropeptides in the energy metabolism and immune regulation of male reproduction. Chem Biol Lett 8:202–212
CAS
Google Scholar
Kim B, Park K, Rhee K (2013) Heat stress response of male germ cells. Cell Mol Life Sci 70:2623–2636
Article
CAS
PubMed
Google Scholar
Leisegang K, Sengupta P, Agarwal A, Henkel R (2020) Obesity and male infertility: mechanisms and management. Andrologia. 53:e13617
Leisegang K, Dutta S (2020) Do lifestyle practices impede male fertility? Andrologia. 53(1):e13595
Agarwal A, Sengupta P (2020) Oxidative stress and its association with male infertility. In: Male infertility. Springer, Cham, pp 57–68
Selvam MKP, Sengupta P, Agarwal A (2020) Sperm DNA fragmentation and male infertility. In: Genetics of male infertility. Springer, Cham, pp 155–172
Alahmar AT, Calogero AE, Sengupta P, Dutta S (2020) Coenzyme q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia. World J Men's Health 39:346–351
De Rooij D, Van Alphen M, Van de Kant H (1986) Duration of the cycle of the seminiferous epithelium and its stages in the rhesus monkey (Macaca mulatta). Biol Reprod 35:587–591
Article
PubMed
Google Scholar
Hikim AS, Swerdloff RS (1999) Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod 4:38–47
Article
CAS
Google Scholar
Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P (1997) An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16:2262–2270
Article
CAS
PubMed
PubMed Central
Google Scholar
Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885
Article
CAS
PubMed
Google Scholar
Jia Y-F, Feng Q, Ge Z-Y, Guo Y, Zhou F, Zhang K-S et al (2018) Obesity impairs male fertility through long-term effects on spermatogenesis. BMC Urol 18:42
Article
PubMed
PubMed Central
Google Scholar
Xin W, Li X, Lu X, Niu K, Cai J (2011) Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia. Int J Mol Med 27:503–509
CAS
PubMed
Google Scholar
Li C, Dong Z, Lan X, Zhang X, Li S (2015) Endoplasmic reticulum stress promotes the apoptosis of testicular germ cells in hyperlipidemic rats. Nat J Androl 21:402–407
CAS
Google Scholar
Sengupta P (2013) Environmental and occupational exposure of metals and their role in male reproductive functions. Drug Chem Toxicol 36:353–368
Article
CAS
PubMed
Google Scholar
Sengupta P, Banerjee R (2014) Environmental toxins: alarming impacts of pesticides on male fertility. Hum Exp Toxicol 33:1017–1039
Article
PubMed
Google Scholar
Sengupta P, Dutta S, D’Souza U, Alahmar A (2020) Reproductive tract infection, inflammation and male infertility. Chem Biol Lett 7:75–84
CAS
Google Scholar
Dutta S, Sengupta P, Izuka E, Menuba I, Jegasothy R, Nwagha U (2020) Staphylococcal infections and infertility: mechanisms and management. Mol Cell Biochem 474:57–72
Article
CAS
PubMed
Google Scholar
Dutta S, Sengupta P (2021) Sars-Cov-2 and male infertility: possible multifaceted pathology. Reprod Sci 28:23–26
Article
CAS
PubMed
Google Scholar
Dutta S, Henkel R, Sengupta P, Agarwal A (2020) Physiological role of ROS in sperm function. In: Male infertility. Springer, Cham, pp 337–345
Chapter
Google Scholar
Khalafalla K, Sengupta P, Arafa M, Majzoub A, Elbardisi H (2020) Chromosomal translocations and inversion in male infertility. In: Genetics of male infertility. Springer, Cham, pp 207–219
Chapter
Google Scholar
Bonde JPE, Ernst E, Jensen TK, Hjollund NHI, Kolstad H, Scheike T et al (1998) Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet. 352:1172–1177
Article
CAS
PubMed
Google Scholar
Slama R, Eustache F, Ducot B, Jensen TK, Jørgensen N, Horte A et al (2002) Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod 17:503–515
Article
CAS
PubMed
Google Scholar
Sermondade N, Faure C, Fezeu L, Shayeb A, Bonde JP, Jensen TK et al (2012) Bmi in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231
Article
PubMed
PubMed Central
Google Scholar
Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW (2008) Male obesity and alteration in sperm parameters. Fertil Steril 90:2222–2225
Article
PubMed
Google Scholar
Dutta S, Sengupta P, Muhamad S (2019) Male reproductive hormones and semen quality. Asian Pac J Reprod 8:189
Article
CAS
Google Scholar
Du Plessis SS, Cabler S, McAlister DA, Sabanegh E, Agarwal A (2010) The effect of obesity on sperm disorders and male infertility. Nat Rev Urol 7:153
Article
PubMed
Google Scholar
Ramlau-Hansen CH, Thulstrup AM, Nohr E, Bonde JP, Sørensen T, Olsen J (2007) Subfecundity in overweight and obese couples. Hum Reprod 22:1634–1637
Article
CAS
PubMed
Google Scholar
Hammiche F, Laven J, Boxmeer J, Dohle G, Steegers E, Steegers-Theunissen R (2011) Sperm quality decline among men below 60 years of age undergoing IVF or ICSI treatment. J Androl 32:70–76
Article
CAS
PubMed
Google Scholar
Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE (2006) Impact of body mass index values on sperm quantity and quality. J Androl 27:450–452
Article
PubMed
Google Scholar
Tunc O, Bakos H, Tremellen K (2011) Impact of body mass index on seminal oxidative stress. Andrologia. 43:121–128
Article
CAS
PubMed
Google Scholar
Sermondade N, Dupont C, Faure C, Boubaya M, Cédrin-Durnerin I, Chavatte-Palmer P, Sifer C, Lévy R (2013) Body mass index is not associated with sperm–zona pellucida binding ability in subfertile males. Asian J Androl 15:626
Article
PubMed
PubMed Central
Google Scholar
Sermondade N, Faure C, Fezeu L, Lévy R, Czernichow S (2012) Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med 172:440–442
Article
PubMed
PubMed Central
Google Scholar
Benchaib M, Lornage J, Mazoyer C, Lejeune H, Salle B, Guerin JF (2007) Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome. Fertil Steril 87:93–100
Article
CAS
PubMed
Google Scholar
Selvam MKP, Agarwal A (2018) A systematic review on sperm DNA fragmentation in male factor infertility: laboratory assessment. Arab J Urol 16:65–76
Article
Google Scholar
Mahfouz R, Sharma R, Thiyagarajan A, Kale V, Gupta S, Sabanegh E, Agarwal A (2010) Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species. Fertil Steril 94:2141–2146
Article
CAS
PubMed
Google Scholar
Agarwal A, Majzoub A, Esteves SC, Ko E, Ramasamy R, Zini A (2016) Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios. Transl Androl Urol 5:935
Article
PubMed
PubMed Central
Google Scholar
Agarwal A, Cho C-L, Esteves SC (2016) Should we evaluate and treat sperm DNA fragmentation? Curr Opinion Obs Gynecol 28:164–171
Article
Google Scholar
Jarow J, Sigman M, Kolettis P (2011) The optimal evaluation of the infertile male: best practice statement reviewed and validity confirmed 2011. American Urological Association, Linthicum, MD, USA.
Google Scholar
Sakkas D, Alvarez JG (2010) Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril 93:1027–1036
Article
CAS
PubMed
Google Scholar
Fariello RM, Pariz JR, Spaine DM, Cedenho AP, Bertolla RP, Fraietta R (2012) Association between obesity and alteration of sperm DNA integrity and mitochondrial activity. BJU Int 110:863–867
Article
CAS
PubMed
Google Scholar
La Vignera S, Condorelli RA, Vicari E, Calogero AE (2012) Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters. J Androl 33:53–58
Article
PubMed
Google Scholar
Rybar R, Kopecka V, Prinosilova P, Markova P, Rubes J (2011) Male obesity and age in relationship to semen parameters and sperm chromatin integrity. Andrologia. 43:286–291
Article
CAS
PubMed
Google Scholar
Yudkin J (2007) Inflammation, obesity, and the metabolic syndrome. Horm Metab Res 39:707–709
Article
CAS
PubMed
Google Scholar
Fan W, Xu Y, Liu Y, Zhang Z, Lu L, Ding Z (2018) Obesity or overweight, a chronic inflammatory status in male reproductive system, leads to mice and human subfertility. Front Physiol 8:1117
Article
PubMed
PubMed Central
Google Scholar
Liew FF, Dutta S, Sengupta P, Chhikara BS (2021) Chemerin and male reproduction:‘a tangled rope’connecting metabolism and inflammation. Chem Biol Lett 8:224–237
CAS
Google Scholar
Akhigbe R, Dutta S, Sengupta P, Chhikara BS (2021) Adropin in immune and energy balance:‘a molecule of interest’in male reproduction. Chem Biol Lett 8:213–223
CAS
Google Scholar
Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Brit J Nutr 92:347–355
Article
CAS
PubMed
Google Scholar
Tsigos C, Papanicolaou DA, Kyrou I, Raptis SA, Chrousos GP (1999) Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J Interferon Cytokine Res 19:1271–1276
Article
CAS
PubMed
Google Scholar
Alahmar A, Dutta S, Sengupta P (2019) Thyroid hormones in male reproduction and infertility. Asian Pac J Reprod 8:203
Article
CAS
Google Scholar
Dutta S, Sengupta P, Chhikara BS (2020) Reproductive inflammatory mediators and male infertility. Chem Biol Lett 7:73–74
Google Scholar
Krajewska-Kulak E, Sengupta P (2013) Thyroid function in male infertility. Front Endocrinol 4:174
Article
Google Scholar
Sengupta P, Dutta S (2018) Thyroid disorders and semen quality. Biomed Pharmacol J 11:01–10
Article
CAS
Google Scholar
Dutta S, Sengupta P, Chhikara BS (2021) Immunoendocrine regulation of energy homeostasis and male reproduction. Chem Biol Lett 8:141–143
Google Scholar
Sengupta P, Bhattacharya K, Dutta S (2019) Leptin and male reproduction. Asian Pac J Reprod 8:220
Article
CAS
Google Scholar
Dutta S, Sengupta P, Biswas A (2019) Adiponectin in male reproduction and infertility. Asian Pac J Reprod 8:244
Article
CAS
Google Scholar
Kyrou I, Tsigos C (2008) Chronic stress, visceral obesity and gonadal dysfunction. Hormones. 7:287–293
Article
PubMed
Google Scholar
Dutta S, Biswas A, Sengupta P, Nwagha U (2019) Ghrelin and male reproduction. Asian Pac J Reprod 8:227
Article
CAS
Google Scholar
İrez T, Karkada IR, Dutta S, Sengupta P (2019) Obestatin in male reproduction and infertility. Asian Pac J Reprod 8:239–243
Article
Google Scholar
Fijak M, Bhushan S, Meinhardt A (2017) The immune privilege of the testis. In: Immune infertility. Springer, Cham, pp 97–107
Chapter
Google Scholar
Sengupta P, Arafa M, Elbardisi H (2019) Hormonal regulation of spermatogenesis. In: Molecular signaling in spermatogenesis and male infertility. CRC Press, Informa UK Limited, UK, pp 41–49
Chapter
Google Scholar
Dutta S, Majzoub A, Agarwal A (2019) Oxidative stress and sperm function: a systematic review on evaluation and management. Arab J Urol 17:87–97
Article
PubMed
PubMed Central
Google Scholar
Agarwal A, Leisegang K, Sengupta P (2020) Oxidative stress in pathologies of male reproductive disorders. In: Pathology. Academic Press, UK, pp 15–27
Chapter
Google Scholar
Carneiro FS, Webb RC, Tostes RC (2010) Emerging role for TNF-α in erectile dysfunction. J Sex Med 7:3823–3834
Article
CAS
PubMed
PubMed Central
Google Scholar
Kulshrestha R, Chaudhuri GR, Bhattacharya K, Dutta S, Sengupta P (2020) Periodontitis as an independent factor in pathogenesis of erectile dysfunction. Biomed Pharmacol J 13:01–04
Article
CAS
Google Scholar
Miranda RA, Agostinho AR, Trevenzoli IH, Barella LF, Franco CC, Trombini AB et al (2014) Insulin oversecretion in MSG-obese rats is related to alterations in cholinergic muscarinic receptor subtypes in pancreatic islets. Cell Physiol Biochem 33:1075–1086
Article
CAS
PubMed
Google Scholar
Kolotkin RL, Zunker C, Østbye T (2012) Sexual functioning and obesity: a review. Obesity. 20:2325–2333
Article
PubMed
Google Scholar
Moon KH, Park SY, Kim YW (2019) Obesity and erectile dysfunction: from bench to clinical implication. World J Men’s Health 37:138–147
Article
Google Scholar
Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB (2003) Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 139:161–168
Article
PubMed
Google Scholar
Demir O, Akgul K, Akar Z, Cakmak O, Ozdemir I, Bolukbasi A, Can E, Gumus BH (2009) Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome. Aging Male 12:29–34
Article
CAS
PubMed
Google Scholar
Chia S, Qadan M, Newton R, Ludlam CA, Fox KA, Newby DE (2003) Intra-arterial tumor necrosis factor-α impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans. Arterioscler Thromb Vasc Biol 23:695–701
Article
CAS
PubMed
Google Scholar
Levinson I, Khalaf I, Shaeer K, Smart D (2003) Efficacy and safety of sildenafil citrate (Viagra®) for the treatment of erectile dysfunction in men in Egypt and South Africa. Int J Impot Res 15:S25–S29
Article
CAS
PubMed
Google Scholar