Table 4 MiRNAs expression profiles in PCOS

miR-29a-5p

Human (GCs)

Klotho gene

Associated with elevated expression of the klotho gene in ovarian granulosa cells of PCOS patients.

[116]

miR-126-5p

Human, rat (GC)

Klotho-associated signaling

Linked to the cellular apoptosis

[116]

miR-29a-3p

Human

STARD3 and androgen receptor

Steroid production and action

[117]

miR-320

Human

STARD3 and androgen receptor

Correlated with alanine-amino transferase and fasting glucose in PCOS patients

[117]

let-7b

Human (Serum)

Activin receptor I and Smad2/3

Linked to folliculogenesis

[118]

miR-30a

Human (FF)

FOXL-2

Ovarian development

[119]

miR-92a

Human

IRS-2, GATA6

Related to androgen biosynthesis in theca cells

[120]

miR-483-5p

Human

Notch3, MAPK3

Connected to cellular proliferation and cell death

[121]

miR-93

Human (GC)

TGFBR2, SMAD7, AR binding, GLUT4, CDKN1A

Associated with insulin resistance and the proliferative condition of GCs in PCOS

[49]

miR-93

Human (Ovarian tissue)

GLUT 4, MCM7

Related to insulin resistance

[122]

miR-93

Human (Granulose cell)

CDKN1A

Promote cell proliferation

[123]

miR-132

Human (FF)

HMGA2

Promote estradiol secretion

[124]

miR-145, miR-320

Human (Granulose cell)

IRS1

Suppress cell proliferation

[125]

miRNA-200b, miRNA-429

Human (Serum)

-

Associated with the pituitary control of ovulation in humans.

[126]

miR-233

Human (Adipose tissue)

GLUT4

Associated with insulin resistance

[127]

miR-320

Human

IRS-1

Reduce insulin resistance in individuals with PCOS by adjusting the ERK1/2 signaling pathway regulated through IRS-1.

[128]

miR-320

Human (FF/GC)

E2F1, SF-1

Slow down the cell growth rate and the synthesis of estradiol.

[129]

miR-509-3p

Human (Cumulus cells)

MAP3K8

Enhanced release of estradiol

[130]

miRNA-592

Human

LHCGR

Restrict cell survival and progression through the cell cycle.

[131]