Table 1 MicroRNA expression profile in folliculogenesis

miR-21; miR-503

Sheep

–

Repressed cell cycle and angiogenesis inhibitor

[26]

miR-143

Mice

Cyclin D2, CDK4, CDK6

Inhibited formation of primordial follicles;

[27]

miR-43 s

Pig

INHBB

Promoted granulosa cells apoptosis;

[28]

miR-133b

TAGLN2

Regulated oocyte maturation;

[29]

miR-200b; miR-429

Mice

ZEB1

Supported ovulation by function in the HPA axis

[30]

miR-21

Mice

LNA-21

Inhibited apoptosis, increases ovulation rate;

[18, 31]

miR-182

Human

SMAD7

[32]

miR-26b

Pig

ATM; SMAD4; HAS2

Inhibited FGCs apoptosis;

[33, 34]

miR-34a

Pig

INHBB

Promoted GC apoptosis;

[28]

miR-92a

Pig

SMAD7

Promoted GC apoptosis;

[35]

Let-7 g

Pig

MAP3K1; TGBR1; IGF1R

Inhibited SMAD7 and promoted apoptosis;

[36, 37]

miR-15a

Human

–

Induced GC and FGCs apoptosis;

[38]

miR-125a

Mice

STAT3

Promoted progesterone and testosterone release

[39]

miR-320

Mouse

E2f1-Sf-1

Enhanced cleaved caspase-3 and promoted FGC apoptosis

[40]

miR-126

Pig

FSHR

Inhibited the synthesis of E2 and proliferation of FGC

[41]

miR-378

Porcine

CYP19A1

Inhibited FSHR and induced FGC apoptosis;

[42]

miR-224

Mice

TGF-1;

Decreased E2 production;

[43]

SMAD4

Enhanced TGF-1 induced and FGC proliferation;

[44]

miR-125b

Yak

BMPR1B

Regulated apoptosis of FGC;

[45]

miR-1275

Pig

LRH-1

Promoted early apoptosis of FGCs;

[46]

miR-503/351/322 cluster

Mouse

AMAG

Reduced the activity of mitochondria in FGCs;

[47]

miR-22

Mice

SIRT1

Suppressed SIRT1 and inhibited FGCs apoptosis;

[48]

miR-141-3p

Rat

DAPK1

Inhibited apoptosis in rat ovarian GCs;

[49]

miR-145

Human

IRS1

Regulated negatively FGC proliferation;

[50]

Mice

KLF4

Protected FGCs against oxidative stress-induced apoptosis

[50]