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Table 4 Comparison of between mirena and metformin groups in regard to side effects

From: Metformin versus levonorgestrel-releasing intrauterine system in the management of endometrial hyperplasia: a randomized clinical trial

Clinical characteristics

Mirena group N (%) (n = 25)

Metformin group N (%) (n = 25)

Test value

p-value

Side effects

 Absent

10 (40%)

12 (48%)

0.35

0.50a

 Present

15 (60%)

13 (52%)

Adverse eventsc

 GIT upset

0 (0)

9 (36%)

9.6

0.004b

 Heavy bleeding at first use

2 (8%)

0 (0)

2.1

0.5b

 Abdominal/pelvic pain

5 (20%)

3 (12%)

0.8

0.7b

 Hypoglycemia

0 (0)

4 (16%)

4.3

0.1b

 Nervousness

2 (8%)

0 (0)

2.1

0.5b

 Depression

2 (8%)

0 (0)

2.1

0.5b

 Headache

4 (16%)

0 (0)

4.3

0.1b

 Back pain

4 (16%)

0 (0)

4.3

0.1b

 Myalgia

0 (0)

2 (8%)

2.1

0.5b

 Weight gain

2 (8%)

0 (0)

2.1

0.5b

 Breast tenderness

3 (12%)

0 (0)

2.1

0.5b

  1. ap-values are based on Chi-square test. Statistical significance at P < 0.05
  2. bp-values are based Fisher Exact test. Statistical significance at P < 0.05
  3. cFrom patients with present side effects