Table 2 PCOS-associated genes enriched with their respective metabolic pathways in KEGG pathway, Reactome pathway, and WikiPathway databases and corresponding OMIM phenotype IDs
Genes | Description of the pathways | OMIM phenotypes ID |
|---|---|---|
HSD3B2 | Steroid hormone biosynthesis | 201810 |
Ovarian steroidogenesis | ||
Cortisol biosynthesis and secretion | ||
Mineralocorticoid biosynthesis | ||
Glucocorticoid biosynthesis | ||
Androgen biosynthesis | ||
Metabolism of steroid hormone | ||
Alternative pathway of fetal androgen synthesis | ||
Peroxiredoxin-2 induced ovarian failure | ||
HSD11B1 | Steroid biosynthesis | 614662, 601283 |
Cortisol synthesis and secretion | ||
Ovarian steroidogenesis | ||
Mineralocorticoid biosynthesis | ||
Glucocorticoid biosynthesis | ||
Androgen biosynthesis | ||
Metabolism of steroid | ||
LMNA | Meiotic synapsis | 115200, 605588, 181350, 616516, 610140, 176670, 151660, 212112, 248370, 613205, 619293 |
Familial partial lipodystrophy (FPLD) | ||
Progeria-associated lipodystrophy | ||
Overlap between signal transduction pathways contributing to LMNA laminopathies | ||
PPARG | Insulin resistance | 609338, 604367, 601665, 125853 |
Growth hormone synthesis, secretion, and actions | ||
Estrogen signaling pathway | ||
Wnt pathway | ||
Pathways in cancer | ||
Estrogen dependent genes expression | ||
Cellular response to stress | ||
Energy metabolism | ||
Androgen receptor signaling pathways | ||
Male infertility | ||
Integrated breast cancer pathways | ||
PP1R3A | Insulin resistance | 125853 |
Insulin signaling pathway | ||
Type 2 diabetes | ||
Ovarian steroidogenesis | ||
Oocytes meiosis | ||
Prolactin signaling pathway | ||
Oxytocin signaling pathways | ||
PLIN1 | Insulin signaling pathway | 613877, 261550 |
Regulation of lipolysis in adipocytes | ||
PPAR signaling pathway | ||
Metabolism of lipids | ||
AMH | TGF-beta signaling pathway | 261550, 184700 |
Signaling pathways regulating pluripotency of stem cells | ||
Transcriptional regulation of testis differentiation | ||
Signaling by BMP | ||
Somatic sex determination | ||
Mammalian disorder of sexual development | ||
AR | Endometrial cancer | 300068, 312300, 300633, 313200, 176807 |
Estrogen signaling pathway | ||
Endocrine resistance | ||
Prolactin signaling pathway | ||
Fluid shear stress and atherosclerosis | ||
Breast cancer | ||
Cushing syndrome | ||
Developmental biology | ||
Androgen receptor signaling pathways |