The insulin-like growth factor and its players: their functions, significance, and consequences in all aspects of ovarian physiology

Afradiasbagharani, Parivash; Hosseini, Elham; Allahveisi, Azra; Bazrafkan, Mahshid

doi:10.1186/s43043-022-00119-1

Middle East Fertility Society Journal

Table 1 The involvement of IGF in ovarian physiology and infertility

From: The insulin-like growth factor and its players: their functions, significance, and consequences in all aspects of ovarian physiology

Author and ref.	Year	Model	Effects mediated by IGF
Dri et al. [15]	2021	Metabolic disorder	Impaired the ovarian reserve, survival, and quality of the eggs
Firmansyah et al. [16]	2022	Polycystic ovarian syndrome	Insulin resistance with compensatory hyperinsulinemia-induced androgen overproduction
Dai et al. [17]	2022	Three-dimensional culture of ovarian preantral follicles	Three-dimensional culture of ovarian preantral follicles
Walters et al. [34]	2006	Bovine antral follicles	Increased size of follicle
			Increased production of estradiol
			Increased health of oocytes
Mani et al. [29]	2010	Bovine granulosa cells	Increased rate of proliferation
			Increases production of estradiol
			Increased production of HSD3B1, CYP11A1, BAX, CYP19A1, FSHR, and IGF1R
Zhou et al. [35]	2005	Caprine preantral follicles	Increased rate of proliferation
Zhou et al. [35]	2005	Caprine preantral follicles	Increased survival rate of preantral follicle
Magalhaes-Padilha et al. [22]	2012	Caprine preantral follicles	Increased rate of normal follicles
			Increase rate of antrum formation
			Increased meiotic resumption in rates
Baumgarten et al. [21]	2014	Cumulus granulosa cell in human	Increased rate of proliferation
			Increased rate of differentiation
			PI3K/AKT mediated
Zhou et al. [36]	1997	Ovaries in mice	Increased production of granulosa cell FSHR
Hastie et al. [37]	2006	Ovine ovary	Increased IGF-2 expression in large follicles
			Decreased IGF-2 expression in atretic follicles
			Increased IGFBP-5 expression in atretic follicles
Campbell et al. [25]	1995	Ovine and bovine granulosa cells	Increased rate of cell proliferation
Campbell et al. [25]	1995	Ovine and bovine granulosa cells	Increased production of estradiol
Guthrie et al. [38]	1998	Granulosa cell culture of pig	Decreased induction of spontaneous apoptosis
Zhao et al. [26]	2001	Preantral follicle in rats	Increased diameter of follicle
			Promoted morphology of follicle
			Increased cortical granules

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