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Fig. 10 | Middle East Fertility Society Journal

Fig. 10

From: Development and evaluation of novel rodent model of PCOS mimicking clinical phenotype in human disease

Fig. 10

Histopathology analysis of ovary and uterine of experimental animals. a Control: normal ovarian depicts the presence of graafian follicle, ovum surrounded by corona radiata, graafian follicle, antrum (fluid filled space), and zona granulosa layer; b DHT: large antral follicles and thickened theca interna cell layer and atresia follicle; c DHT + F: multiple atresia cystic follicles; d Fructose: normal graafian follicles; e DHT + F + C: the presence of a developing follicle which contains the antrum and ovum which is surrounded by granulosa cells; f DHT + F + M: the presence of follicles with a typical presentation, exhibiting features like the presence of antral follicles at different stages of development and showing at least one graafian follicle with a mature ovum in it; g DHEA: the pre-antral follicle is observed which is surrounded by the layer of theca interna cells and theca externa. h DHEA + F: secondary and cystic follicles; i uterine DHT, thick endometrium; j uterine DHT + F, thinned endometrium (hematoxylin and eosin stain, × 10 magnification)

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