The need to identify novel biomarkers for prediction of premature ovarian insufficiency (POI)

Middle East Fertility Society Journal

Table 1 List of potential protein biomarkers in POI

Proteins	Expression status	Sample	Reference(s)
Granulin	↓	Human	[41]
ADAMTS-19	↓	Human	[43]
Fdx1	↓	Mouse	[44]
Cyp17a1	↓	Mouse	[44]
Cyp11a1	↓	Mouse	[44]
Cyp2u1	↓	Mouse	[44]
Ceruloplasmin	↑	Human	[45]
Complement C3	↑	Human	[45]
Fibrinogen α	↑	Human	[45]
Fibrinogen β	↑	Human	[45]
SHBG	↑	Human	[45]
Neurturin	↓	Human	[46]
Frizzled-5	↓	Human	[46]
Serpin D1	↓	Human	[46]
MMP-7	↓	Human	[46]
ICAM-3	↓	Human	[46]
IL-17F	↓	Human	[46]
IFN-gamma R1	↓	Human	[46]
IL-29	↓	Human	[46]
IL-17R	↓	Human	[46]
IL-17C	↓	Human	[46]
Soggy-1	↓	Human	[46]
Afamin	↑	Human	[46]
USP12	↑	Human ovarian cancer cell line	[47]
COPS5	↑	Human ovarian cancer cell line	[47]
ATXN3L	↑	Human ovarian cancer cell line	[47]
USP49	↑	Human ovarian cancer cell line	[47]
USP34	↓	Human ovarian cancer cell line	[47]