Predicting the testicular function in non-obstructive azoospermia via targeted gene panel

Middle East Fertility Society Journal

Table 3 Effect of gene expression level on ICSI outcome in patients positive for testicular sperm

	High vs low OR (95% CI; p)	Medium vs low OR (95% CI; p)	log (expressed gene) OR ((95% CI; p)
Ongoing pregnancy: 21/59 (36%)	1.89 (0.31 to 7; 0.83)	0.34 (0.1 to 9; 0.78)	1.04 (0.94 to 1.15; 0.49)
Good sperm concentration: 37/59 (62%)	1.12 (0.18 to 7.35; 0.98)	2.21 (0.15 to 18.92; 0.97)	1.00 (0.58 to 1.72; 0.99)
Oocyte level analysis
Fertilization rate per injected oocyte: 337/561 (60%)	0.86 (0.42 to 1.63; 0.97)	0.72 (0.28 to 1.72; 0.80)	0.99 (0.94 to 1.04; 0.99)
Utilized embryos per fertilized oocyte: 214/ 561 (38%)	0.71 (0.42 to 1.33; 0.25)	0.75 (0.37 to 1.60; 0.49)	0.97 (0.93 to 1.01; 0.15)

Data comparisons were by generalized mixed model with bootstrap: logistic regression was done at oocyte level or patient level, as appropriate. All analyses were adjusted for age as covariate after standardization. The upper set in the table represents a patient-level analysis, while the lower set represents an oocyte-level analysis. The effect sizes are summarized as odds ratio, with 95% confidence intervals