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Table 2 Comparison of the cycle and pregnancy outcomes between groups

From: Early administration of gonadotropin-releasing hormone antagonist versus flexible antagonist ovarian stimulation protocol in poor responders: a randomized clinical trial

 

Experimental group

(n = 58)

Control group

(n = 58)

P value

Duration of stimulation (days)

10.12 ± 2.28

10.0 ± 1.50

0.76

No. of used antagonist ampoule

10.12 ± 2.28

3.93 ± 1.32

< 0.0001*

Total ampoules of used gonadotropins (75 IU)

47.2 ± 12.7

43.7 ± 10.4

0.11

Serum estradiol on HCG day

524 ± 78.29

358± 51.21

0.23

Serum progesterone on HCG day

0.61 ± 0.37

0.52 ± 0.28

0.17

Serum LH level on HCG day

2.60± 3.14

3.23± 5.66

0.52

No. of retrieved oocytes

4.17 ± 2.89

3.20 ± 2.47

0.07

No. of metaphase II oocytes

3.35 ± 2.55

2.46 ± 2.20

0.04*

Fertilization rate

0.77 ± 0.24

0.79 ± 0.25

0.5

No. of obtained embryo

2.61 ± 1.45

2.13± 1.47

0.17

No. of top quality embryos

1.68 ± 1.63

1.37± 1.41

0.30

Cycle cancelation rate; n (%)

5/84 (5.9)

2/74 (2.7)

0.43

No. of embryos transferred

2.20 ± 0.67

1.73 ± 1.08

0.13

Endometrial thickness on ET day (mm)

9.34 ± 1.14

9.08 ± 0.98

0.19

Implantation rate

0.58 ± 0.39

0.33 ± 0.28

0.36

Clinical pregnancy rate per ET (%)

40%

11.1%

0.02*

Miscarriage rate per ET (%)

6.6%

3.9%

0.53

Ongoing pregnancy rate per ET (%)

33.4%

7.2%

0.03*

  1. Descriptive data were presented as Mean ± SD. P value ≤ 0.05 was considered statistically significant
  2. Between-group comparisons were performed by Student’s t test for the data with normal distribution and by the Mann–Whitney U test for non-parametric data. Further, the chi-square test was used for comparing the categorical variables between groups
  3. HCG human chorionic gonadotropin, LH luteinizing hormone, ET embryo transfer
  4. *P value ≤ 0.05 was considered statistically significant