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Table 3 Studies for POI

From: Intraovarian platelet-rich plasma: current status

Study

Type of study

Number of patients

Outcome

Pantos et al. 2019 [5]

Case series

8

All cases underwent natural IVF cycles: follicles of 15.20 ± 2.05 mm in diameter, ICSI and all resulting embryos were cryopreserved.

Sfakianoudis et al. 2019 [3].

Case report

1

Significant reduction in FSH. IVF: biochemical pregnancy: spontaneous abortion at the 5th week

Cakiroglu et al. 2020 [16]

Interventional

311

7.4%conceived spontaneously, 64.8% developed AFC and attempted IVF. IVF: PR/ET: 22.8% (4% of total). LBR: 8%

Hsu et al. 2020 [17]

Case report

1

3 cleavage stage embryos were transferred, leading to a successful pregnancy

Elsherbiny, 2020 [7]

Case report

1

Increased AMH and E2 and decreased serum FSH and LH. Natural pregnancy.

Barad et al. 2020 [18]

Prospective registered studies

51: G1: 20: POI. G2: 31: POA/

oPOI

G1: over first 60 days revealed no changes in E2 or FSH levels although 4/20 (20%) demonstrated follicle growth.

G2: sig fall in E2 and rise in FSH over the first 30 days, then a rise in E2 and drop in FSH.

Hsu et al. 2021 [19]

Interventional

12

Decrease FSH and LH. Two participants had cleavage stage embryos transferred, of which one achieved clinical pregnancy.

Aflatoonian et al. 2021 [15]

Case series

9

No significant difference in FSH or LH was detected

Total

 

394

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