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Table 6 Semen parameters according to the various genotypes of rs8177404 and rs3828599 polymorphisms in fertile (n=100) and infertile group (n=100)

From: Glutathione peroxidase 3 (extracellular isoform) levels and functional polymorphisms in fertile and infertile men

Genotypes Sperm motility1 (%) Sperm concentration (million/ml) Sperm normal morphology (%)
Progressively motile sperm Non-progressively motile sperm Immotile sperm
GPX3, rs8177404
Fertile group
  TT (n=77) 35.44±8.03 35.95±5.35 30.83±6.42 64.23±10.13 18.78±6.90
  TC (n=16) 31.31±7.28 34.76±7.27 36.93±8.55a 59.14±9.12 16.78±9.23
  CC (n=7) 23.17±9.34a,b 32.52±6.10 44.21±4.71a,b 56.77±11.10 13.28±5.82a
Infertile group
  TT (n=59) 15.16±5.21 31.14±8.92 53.43±16.71 40.14±12.11 6.14±3.01
  TC (n=28) 11.10±8.63a 28.03±9.04 59.18±11.29 35.46±12.08 5.08±4.26
  CC (n=13) 8.72±5.12a 27.73±8.19 62.19±7.38 30.16±10.61a 4.37±2.84
GPX3, rs3828599
Fertile group
  AA (n=45) 27.01±9.82 29.94±10.73 39.03±10.76 57.25±17.43 16.89±10.20
  AG (n=31) 29.38±8.06 32.02±8.67 38.37±12.72 58.92±15.40 19.01±7.83
  GG (n=24) 31.49±6.27a 30.93±10.53 37.82±13.01 64.18±12.52 18.07±8.81
Infertile group
  AA (n=61) 13.79±8.30 29.10±11.42 57.23±10.63 38.01±14.12 5.43±2.91
  AG (n=28) 16.01±6.05 31.88±7.91 52.71±17.87 37.74±15.04 4.62±3.91
  GG (n=11) 17.38±6.71 32.07±7.20 49.82±13.63a 41.27±11.92 5.05±3.66
  1. Results are presented as mean ± SD
  2. 1Grade of sperm movement according to WHO [2010] criteria
  3. Significant difference in comparison with awild type and bheterozygous variant