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Table 5 The frequency of GPX3 rs3828599 (A to G) genotypes, alleles, and odds ratios in fertile (n = 100) and infertile (n = 100) males using χ2 test and regression logistics analysis

From: Glutathione peroxidase 3 (extracellular isoform) levels and functional polymorphisms in fertile and infertile men

Gene and polymorphism Information Genotypes frequencies p-Value (χ2, df) Odds ratio, 95% CI (Lower-Upper, p)
Gene name/symbol Glutathione peroxidase 3/GPX3   Fertile (n) Infertile (n)   
Entrez ID/location 2878/5q33.1 AA 45 61 0.025 (χ2=7.396, df=2) Reference group
Race/Number of participants (infertile-controls) Iranian/100-100 AG 31 28 0.666 (0.351–1.264, p=0.214)
Study approach Tetra-ARMS GG 24 11 0.338 (0.150–0.761, p=0.009)
Disease/Ontology ID Male infertility/12336 AG+GG 55 39 0.023 (χ2=5.138, df=1) 2.093 (0.298–0.918, p=0.024)
Polymorphism ID/location rs3828599/LOC105378228 Alleles frequencies  
Genomic coordinate of the
polymorphism (start-end)
151022235-151022235 A 121 (60.5%) 150 (75%) 0.002 (χ2=9.623, df=1) Reference group
Polymorphism
biotype/Residue change
Intron Variant G 79 (39.5%) 50 (25%) 0.511 (0.333–0.783, p<0.002)