Table 5 The frequency of GPX3 rs3828599 (A to G) genotypes, alleles, and odds ratios in fertile (n = 100) and infertile (n = 100) males using χ2 test and regression logistics analysis
Gene and polymorphism Information | Genotypes frequencies | p-Value (χ2, df) | Odds ratio, 95% CI (Lower-Upper, p) | |||
|---|---|---|---|---|---|---|
Gene name/symbol | Glutathione peroxidase 3/GPX3 | Â | Fertile (n) | Infertile (n) | Â | Â |
Entrez ID/location | 2878/5q33.1 | AA | 45 | 61 | 0.025 (χ2=7.396, df=2) | Reference group |
Race/Number of participants (infertile-controls) | Iranian/100-100 | AG | 31 | 28 | 0.666 (0.351–1.264, p=0.214) | |
Study approach | Tetra-ARMS | GG | 24 | 11 | 0.338 (0.150–0.761, p=0.009) | |
Disease/Ontology ID | Male infertility/12336 | AG+GG | 55 | 39 | 0.023 (χ2=5.138, df=1) | 2.093 (0.298–0.918, p=0.024) |
Polymorphism ID/location | rs3828599/LOC105378228 | Alleles frequencies | Â | |||
Genomic coordinate of the polymorphism (start-end) | 151022235-151022235 | A | 121 (60.5%) | 150 (75%) | 0.002 (χ2=9.623, df=1) | Reference group |
Polymorphism biotype/Residue change | Intron Variant | G | 79 (39.5%) | 50 (25%) | 0.511 (0.333–0.783, p<0.002) | |