Table 4 The frequency of GPX3 rs8177404 (T to C) genotypes, alleles, and odds ratios in fertile (n = 100) and infertile (n = 100) males using χ2 test and regression logistics analysis
Gene and polymorphism information | Genotypes frequencies | p-value (χ2, df) | Odds ratio, 95% CI (lower-upper, p) | |||
|---|---|---|---|---|---|---|
Gene name/symbol | Glutathione peroxidase 3/GPX3 | Â | Fertile (n) | Infertile (n) | Â | Â |
Entrez ID/location | 2878/5q33.1 | TT | 77 | 59 | 0.024 (χ2=7.455, df=2) | Reference group |
Race/Number of participants (infertile-controls) | Iranian/100-100 | TC | 16 | 28 | 2.284 (1.132–4.607, p=0.021) | |
Study approach | Tetra-ARMS | CC | 7 | 13 | 2.424 (0.910–6.454, p=0.076) | |
Disease/Ontology ID | Male infertility/12336 | TC+CC | 49 | 69 | 0.006 (χ2=7.445, df=1) | 2.326 (1.260–4.294, p=0.007) |
Polymorphism ID/location | rs8177404/ LOC105378228 | Alleles frequencies | Â | Â | ||
Genomic coordinate of the polymorphism (start-end) | 151020023- 151020023 | T | 170 (85%) | 146 (73%) | 0.003 (χ2=8.680, df=1) | Reference group |
Polymorphism biotype/Residue change | Non Coding Transcript Variant | C | 30 (15%) | 54 (27%) | 2.096 (1.274–3.449, p=0.004) | |