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Table 4 The frequency of GPX3 rs8177404 (T to C) genotypes, alleles, and odds ratios in fertile (n = 100) and infertile (n = 100) males using χ2 test and regression logistics analysis

From: Glutathione peroxidase 3 (extracellular isoform) levels and functional polymorphisms in fertile and infertile men

Gene and polymorphism information Genotypes frequencies p-value (χ2, df) Odds ratio, 95% CI (lower-upper, p)
Gene name/symbol Glutathione peroxidase 3/GPX3   Fertile
(n)
Infertile
(n)
  
Entrez ID/location 2878/5q33.1 TT 77 59 0.024 (χ2=7.455, df=2) Reference group
Race/Number of participants (infertile-controls) Iranian/100-100 TC 16 28 2.284 (1.132–4.607, p=0.021)
Study approach Tetra-ARMS CC 7 13 2.424 (0.910–6.454, p=0.076)
Disease/Ontology ID Male infertility/12336 TC+CC 49 69 0.006 (χ2=7.445, df=1) 2.326 (1.260–4.294, p=0.007)
Polymorphism ID/location rs8177404/ LOC105378228 Alleles frequencies   
Genomic coordinate of the polymorphism (start-end) 151020023- 151020023 T 170 (85%) 146 (73%) 0.003 (χ2=8.680, df=1) Reference group
Polymorphism biotype/Residue change Non Coding Transcript Variant C 30 (15%) 54 (27%) 2.096 (1.274–3.449, p=0.004)