Table 2 Autologous platelet-rich plasma (PRP) infusion in cases of refractory endometrium
Author, year | Study design | Population | Sample size | Study outcomes |
|---|---|---|---|---|
Chang et al. (2015) [1] | Prospective cohort study | Women who have a poor endometrial response (< 7 mm) to the standard hormonal preparation of FET and had to cancel their embryo transfer. | 5 | Successful endometrial expansion and transfer for all patients with pregnancy detected in 4 cases |
Zadehmodarres et al. (2017) [2] | Prospective cohort study | Patients with a history of canceled FET due to inadequate endometrium. | 10 | ET increased in all patients with Five of them were pregnant |
Molina et al. (2018) [36] | Prospective cohort study | Patients with a history of refractory endometrium. | 19 | ET ≥ 7 m was detected after the first PRP use and all cases experienced ET ≥ 9 mm after the second use. Embryo transfer was conducted in the entire study group. Positive pregnancy in 73.7% with live birth in 26.3% |
Tandulwadkar et al. (2017) | Prospective cohort study | Women experienced suboptimal growth or vascularity despite standard dose of hormonal preparation. Women with > 2 canceled cycles or recurrent implantation failure due to poor endometrial lining. | 68 | ET and vascularity increased post- PRP. Clinical pregnancy was detected in 45.1%. |
Jang et al. (2017) [37] | Animal study | Murine animal model. | 60 | PRP stimulated and accelerated regeneration of the endometrium with decreased fibrosis. |