Table 1 Autologous platelet-rich plasma (PRP) infusion in cases of thin endometrium

Kim et al. (2019) [34]

Prospective interventional study

Patients with history of ≥ 2 failed IVF cycles and refractory thin endometrium (< 7 mm).

24 patients were compared against their previous cycles

PRP improved implantation, pregnancy and live birth rates in comparison to their previous cycles.

Chang et al. (2019) [33]

Prospective interventional study

Patients with thin endometrium < 7 mm and prior canceled FET.

34 in PRP group and 30 in control.

PRP had higher ET and lower cancellation rate.

Higher implantation and clinical pregnancy rate in favor of PRP (27.94% vs 11.67%, P  < .05; 44.12% vs 20%, P  < .05, respectively).

Higher levels of PDGF-AB, PDGF-BB, and TGF-βin favor of PRP group in comparison to peripheral blood.

Eftekhar et al. (2018) [35]

Randomized clinical trial

Women with poor endometrial response to standard hormonal preparation (ET < 7 mm in the 13th day of FET cycle

40 in PRP and 43 in control

PRP higher ET (0.001), implantation (P = 0.002) and pregnancy rate (P = 0.044).

Wang et al. (2018)

Prospective interventional study

Patients with recurrent implantation failure due to suboptimal endometrial pattern,

women with ≥ 2 canceled cycles due to thin endometrial lining

20 patients were compared to their previous data

Successful endometrial expansion after PRP (5.55 ± 0.71 mm vs 7.82 ± 1.04 mm, P < 0.001, for pre- and post-PRP respectively). Pregnancy was positive in 12 cases after PRP infusion (60%)..

In vitro analysis demonstrated that PRP significantly increased growth, migration, and adhesion of endometrial mesenchymal stem cells.