Table 4 The in silico analysis of the observed nonsynonymous SNPs in BMP15 using several bioinformatics tools
SNP | SIFT | PolyPhen-2 | PROVEAN | SNAP2 | I-Mutant2 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Score | Prediction | Score | Prediction | Score | Prediction | Score | Prediction | Score | Prediction |
M4L | 0.00 | Deleterious | 0.994 | Probably damaging | − 2.643 | Deleterious | 48 | Effect | − 0.08 (DDG-kcal/mol) | Decrease stability |